Serum microRNAs in childhood tumors 1 Solid tumors of childhood display specific serum microRNA profiles

1 Solid tumors of childhood display specific serum microRNA profiles Matthew J. Murray, Katie L. Raby, Harpreet K. Saini, Shivani Bailey, Sophie V. Wool, Jane M. Tunnacliffe, Anton J. Enright, James C. Nicholson, Nicholas Coleman. 1 Department of Paediatric Haematology and Oncology, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK 2 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK 3 University of Cambridge Department of Paediatrics, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK 4 European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, CB10 1SD, UK 5 Department of Histopathology, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK Corresponding authors: Dr Matthew Murray and Professor Nicholas Coleman, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. Telephone number: 0044 (0)1223 765066, Fax: 0044 (0)1223 333346. Email: [email protected], [email protected] Conflict of Interest Statement: There are no conflicts to disclose Sources of Financial Support: Cancer Research UK (N. Coleman), Medical Research Council (M.J. Murray), SPARKS (N. Coleman, M.J. Murray, J.C. Nicholson) and Children with Cancer UK/Great Ormond Street Hospital Children’s Charity (N. Coleman, M.J. Murray, K.L. Raby, J.C. Nicholson). Word count: 3999; Figures/tables: total six Short title: Serum microRNAs in childhood tumors